Arsufee 60 Mg Infusion 60 Ml
Artesunate is used to treat symptoms of falciparum malaria caused by the Plasmodium falciparum parasite, especially in quinidine resistant patients. Sulfadoxine is used in combination therapy for the treatment of bacterial infections related to respiratory and urinary tract. Pyrimethamine is one of the folic acid antagonists and anti-parasite. It is used to treat malarial infection and toxoplasmosis.
How does the drug work?
Artesunate is an antimalarial agent. It is a prodrug that is converted into its active form dihydroartemisinin. It inhibits the protein synthesis of malaria cell by alkylation, as a result glutathione in the parasite is reduces which damages the cell. Sulfadoxine is a long-acting sulfonamide. It inhibits the activity of dihydropteroate synthase, which is essential in the bacillus folate synthesis pathway. Pyrimethamine belongs to groups called antiprotozoals. It works by inhibiting dihydrofolate of malaria parasite,thereby blocks the biosynthesis of purines and pyrimidines. These molecules are essential for DNA synthesis and cell replication. Blocking of these molecules caUSES parasitic cell to degrade and lower the infection.
What are the common side effect?
The common side effects of artesunate are cough, dizziness, ECG changes, fever, headache, injection site pain, itching, and upper respiratory tract infection, loss of appetite, nausea, weakness, and diarrhea. The common side effects of Sulfadoxine are abdominal pain, inflammation, headache, ringing in ear, balance disorder, allergy, vertigo, and diarrhea. The common side effects of pyrimethamine are skin pigmentation, anemia, and change in blood test results, dizziness, headache, vomiting, weakness, diarrhea, nausea, and bruising.
• Patients with severe stomach and intestinal problems, neurological problems should consult the doctor before taking Arsufee tablets.
• Arsufee can lower the blood glucose level severely which may result in loss of consciousness and may be life-threatening to patients. Diabetic patients should consult your doctor before taking the medication.
• Avoid Arsufee in the patients with the history of maculopathy or retinopathy.
• Stop Arsufee medication, if disturbances in vision, abnormal color vision, black spots or haziness are experienced
• Patients who are pregnant or planning to become pregnant or breastfeeding should consult the doctor before taking the Arsufee medication.
• Take each dose of Arsufee with food or a glass of milk.
• In children, long-term use of Arsufee is not recommended.
1. I have ECG abnormalities. Is artesunate drug safe for me? No, patients with ECG abnormalities should not take artesunate for malaria.
2. What is the recommended dose for artesunate drug? The artesunate dose for adults is 150mg once a day for three consecutive days.
3. Can quinine and artesunate be used together to treat malaria? Yes, generally artesunate is given along with quinine drugs to treat malaria and other kinds of fever.
4. How often should I have blood tests while using artesunate drug? Patients should have blood test once a week in a month to detect the presence of any malaria parasites.
5. I am suffering from pneumonia and malaria. Can I take artesunate for malaria fever? No, do not take the drug for pneumonia as it may increase the side effects of artesunate. Sulfadoxine
1. Is it necessary to take sulfadoxine along with pyrimethamine? Sulfadoxine, when used along with pyrimethamine, is very effective towards infection. So it is suggested to take both the drugs.
2. Is Sulfadoxine a sulfa drug? Yes, Sulfadoxine belongs to sulpha group.
3. Can I take sulfadoxine along with dapsone? No, sulfadoxine, when taken with dapsone while, have severe adverse effects.
4. How often should I take this drug? Sulfadoxine drug is not recommended to take for longer period due to high levels of resistance.
5. I experience constipation while taking sulfadoxine. Should I stop taking the drug? Constipation is the common side effects of sulfadoxine drug. Inform the doctor before the condition worse. Pyrimethamine
1. I am diagnosed with megaloblastic anemia due to folate deficiency. Can I take pyrimethamine to treat malaria? No, patients with megaloblastic anemia should not take pyrimethamine due to adverse side effects.
2. What drugs should I avoid while taking pyrimethamine? Drugs such as phenytoin, methotrexate, proguanil, quinine, sulfonamides, and zidovudine should be avoided due to the risk of bone marrow suppression.
3. How to take pyrimethamine? Pyrimethamine can be taken with or without food, if stomach upset occurs, take the drug with food.
4. When should I stop taking the drug? The patient should use pyrimethamine for full course of treatment, do not discontinue the drug in the middle of the treatment even if u feel better unless suggested by doctor.
5. Does pyrimethamine cause risk of cancer? Yes, pyrimethamine increases the risk of cancer.