Nebest H 5/12.5 Mg Tablet 10
Nebivolol is a beta-blocker which can be used either as a monotherapy or in combination with other medications for the treatment and management of high blood pressure. It is also used to prevent stroke, heart attack and kidney problems. It is also used for prevention of chest pain in the patients with cardiac disorders. It is used as maintenance therapy in the survivals of heart attack. Hydrochlorothiazide is used to treat hypertension. It is also used in the treatment of fluid retention in congestive heart failure or liver cirrhosis. Hydrochlorothiazide is used as a diuretic to removes excess salts from the body.
How does the drug work?
Nebivolol is a beta1 receptor blocker which causes vasodilatation and reduced blood pressure. Beta1 adrenergic receptors are G- protein coupled receptors and are present in the heart and kidney. These receptors get activated with the help of endogenous catecholamines such as adrenaline and noradrenaline. Adrenaline and noradrenaline are also called as ‘fight-or –flight’ hormone. They cause vasoconstriction and increase the blood pressure. Adrenaline increases heart rate by depolarizing the sinoatrial (SA) node and increases the conduction of Purkinge fibers. Nebivolol blocks the beta1 receptor and inhibits the affects of adrenaline on the heart. Thereby it helps to prevent vasoconstriction and reduces blood pressure. It also decreases heart rate and reduces the risk of stroke. Hydrochlorothiazide acts by eliminating excess salts from the body by inhibiting sodium reuptake in the body. Hydrochlorothiazide blocks sodium-chloride symporter, it reduces osmotic gradient and water reabsorption throughout the body.
What are the common side effect?
The most commonly reported side effects of nebivolol are headache, nausea, stomach pain, diarrhea, insomnia, weight gain, numbness in the hand and feet, chills, uneven heart beats, swelling in the ankle or feet, mild exertion, and shortness of breath. The common reported hydrochlorothiazide symptoms are excessive thirst, abnormal heart rhythms, increased sensitivity to light, dry mouth, skin allergies, headache, GI disorder, decreased potassium levels, and tingling in hands legs and feet.
Important Information for use
• People with bone marrow depression should not use Zepcar CR medicine.
• Avoid the Zepcar CR drug if an allergic reaction was seen with an earlier use of carbamazepine.
• Do not take any other antidepressant drugs along with Carbafen tablet. If a MAO-inhibitor drug was used in the past 14 days, then do not take Zepcar CR.
• Call the doctor immediately in the case of skin rash, unusual weakness, bleeding and fever. This is because of the chances of Carbafen side effects such as life-threatening skin rash.
• Continue the Zepcar CR medication for the full length prescribed by the doctor.
• Pregnant women should not start or stop using Zepcar CR unless instructed by the doctor.
• Don’t get exposed to sunlight due to the risk of sunburn with Zepcar CR.
• Do not take grapefruit juice while using Zepcar CR.
1. What should I do if I miss a dose? If you forget to take the medication at the usual time, you must take it as soon as you remember. If it is time for the next dose, you must skip the missed dose. Do not take double dose.
2. Are there any storage precautions for nebivolol? Store the medication at room temperature (25°C) and away from direct heat. Keep the drug out of reach of children.
3. What long-term effects I might experience with nebivolol? Use of nebivolol can impair renal functioning and increase the blood urea nitrogen levels. So patients should undergo continuous renal monitoring.
4. Is nebivolol used for preventing angina? Yes. nebivolol has nitric oxide-potentiating vasodilator effect and reduces the oxygen demand and prevents ischemia and chest pain (angina).
5. Can I take any other medications along with nebivolol ? You must discuss with your doctor before taking any other medications. Hydrochlorthiazide
1. I am pregnant. Should I stop taking hydrochlorothiazide? Hydrochlorothiazide is safe during pregnancy. However, consult your doctor before taking the drug.
2. I am suffering from thyroid disorder. Can I use hydrochlorothiazide? Discuss with the doctor about the safe use of the drug in thyroid disorders
3. Can I give hydrochlorothiazide to my 15-year-old child? No, hydrochlorothiazide is not recommended for the children younger than 18 years of age.
4. What are the side effects of hydrochlorothiazide in diabetic patients? Hydrochlorothiazide may affect the blood sugar levels of diabetic patients. Talk to your doctor before using the drug.
5. I am allergic to sulpha drugs. Can I take hydrochlorothiazide? No, sulfa drugs may react with hydrochlorothiazide. Discuss with your doctor about the safe use of the drug.