R-Cinex 600/300 Mg Tablet 9
R-Cinex tablet consists of rifampicin which is mainly used in combination with other drugs to treat tuberculosis (TB) and leprosy. Rifampin is also used for the treatment of meningitis (infection of membranes of the brain and spinal cord) or other infections. R-Cinex consists of drug isoniazid which is used to treat and prevent tuberculosis (an infection caused by bacteria that affects the lungs and other parts of the body). Isoniazid is always prescribed in combination with other anti-TB drugs.
How does the drug work?
Rifampin is known as a broad-spectrum antibiotic which means it kills a wide range of infection causing bacteria. Rifampicin blocks the activity of DNA-dependent RNA polymerase (bacterial enzyme) essential for important life processes in the bacteria, thereby killing them. Isoniazid belongs to a class of drugs known as antituberculosis drugs. Isoniazid acts by inhibiting the synthesis of mycolic acid (an essential component of the bacterial cell wall) thereby suppressing their growth.
What are the common side effect?
Rifampicin side effects include nausea and vomiting, diarrhea, loss of appetite, hemolytic anemia, abnormal liver function tests, jaundice, acute renal failure, irritation of ear, allergic skin rash, reduced blood platelets, fever, drowsiness, and headache. The common side effects of isoniazid include nausea and vomiting, inflammation of the optic nerve of the eye, agranulocytosis, peripheral neuropathy, aplastic anemia, hemolytic anemia, diarrhea, dry mouth, gastrointestinal disorder, and hepatitis.
• Inform the doctor about all the current medication before taking R-Cinex tablets as R-cinex interacts with many drugs and reduce the effectiveness of the treatment or aggravate the side effects.
• Patients wearing contact lenses should consult the doctor before taking R-Cinex as rifampin may permanently stain the contact lenses.
• Taking rifampin may produce a brownish-red coloration of the urine, sputum sweat, and tears.
• Patients who are pregnant or planning to become pregnant or breastfeeding or above 65 years should consult the doctor before taking tablet R-Cinex.
• Patients who are on oral contraceptive medications for birth control should use other means of contraceptives while on R-Cinex medication as it may lead to failure of therapy.
• If you take rifampin irregularly or if daily administration is resumed after a drug-free interval, you may experience ‘flu syndrome’.
• Rifampin should be preferably taken in the morning before breakfast. Taking rifampin with food is known to delay its absorption thereby, reducing its effectiveness.
• Do not stop taking R-Cinex tablets without consulting the doctor.
1. Is rifampicin similar to penicillin medications? No. The structure and mechanism of action of rifampicin is different from that of penicillin.
2. Is rifampicin used to treat nasal infections? Yes. It kills the bacteria in the nose and throat thereby treating the nasal infections.
3. What happens if I take rifampicin irregularly? You may experience episodes of fever, chills, dizziness, headache, and bone pain which is commonly known as flu syndrome.
4. Does rifampicin interact with oral contraceptives? Yes, it may interact and reduce the effectiveness of oral contraceptives.
5. I have taken rifampicin without knowing that I am pregnant, does it harm the fetus? Yes. Rifampicin is unsafe during pregnancy and may harm the fetus. Consult your doctor immediately. Isoniazid
1. Why is pyridoxine supplement indicated for patients taking isoniazid? Isoniazid use may lead to a deficiency in pyridoxine as the drug promotes the excretion of pyridoxine in the urine.
2. Does isoniazid affect the potency of birth control pills? Isoniazid has no known interaction with the birth control pills (oral contraceptives). However, when taken along with other anti-TB drugs such as rifampicin may show the failure of contraception.
3. Does isoniazid cause acne? You may experience acne while taking isoniazid. It may be due to the side effects of the drug or a result of drug interaction with other molecules.
4. What is the reason for peripheral neuropathy in the patients taking isoniazid? Isoniazid may lead to a deficiency of vitamin pyridoxine. Pyridoxine deficiency may cause peripheral neuropathy.
5. Do I feel tired or exhausted while using isoniazid medications? Fatigue or tiredness is the side effect of the drug isoniazid.